Explore our Research Blog
Rhein Main Cancer Retreat 2023
Konstantin presents a talk about his project progress at the 4th Rhein Main Cancer Retreat. Other representatives of AG Klusmann were Leah, Anna-Lena and Stephanie presenting respective posters.
Increasing Server Capacity
An exiting delivery has arrived at the lab. A new server cabinet and additonal equipment was setup by our bioinformatics team. The new set up will provide extended data storage and increased computational capacities.
Portrait: Jan-Henning Klusmann as Director of the Pediatric Hospital in Frankfurt
A local newspaper has recently featured a portartit article about our grouplader Prof. Klusmann and his tasks and goals as director of the pediatric hospital in Frankfurt.
RUNX1 publication choosen as Plenary Paper and for Podcast Feature
Our latest Paper was chosen as plenary paper in this weeks Issue of Blood. Along side it is also available as audio summary on the latest Blood Podcast.
RUNX1 isoform disequilibrium promotes the development of ML-DS
Our latest BLOOD paper unravels the importance of RUNX1 isoform equilibrium and its interaction with the oncogenic players GATA1s and the MYC:MAX complex.
3 Mio € Funding promoting the search for new AML Treatments
This week we were awarded a new funding over 2.7 million from the association “Hilfe für krebskranke Kinder”. This money will help us to discovery new therapeutics for pediatric AML.
A new regulator of myeloid leukemia identified
Oriol Alejo-Valle's work was published as a Plenary Paper in BLOOD. We describe the molecular basis for the dual differentiation block in Down syndrome megakaryoblastic leukemia.
Guidelines for diagnosis and treatment of TAM and ML-DS
From the clinical side of our lab: Sina presents recommendations for the diagnosis and treatment of children with transient abnormal myelopoiesis and Down syndrome myeloid leukemia.
Oriol successfully defends his PhD thesis in Halle
Congratulations to Dr. rer. nat. Oriol Alejo-Valle on a successful PhD dissertation! His is the first defense from our group that has been held in Halle, and concludes our "batch from 2015".
Prof. Klusmann becomes Head of Pediatrics in Frankfurt
Another partial lab move is coming up! As of July 1st, Prof. Klusmann has joined the Universitätsklinikum Frankfurt as Head of Pediatrics. Students and postdocs will follow in October.
Review of molecular mechanisms underlying TAM and ML-DS
In our latest review article, we provide a comprehensive overview of the molecular basis of step-wise leukemogenesis in Down syndrome-associated myeloid leukemia and transient abnormal myelopoiesis.
Michelle defends PhD thesis summa cum laude
We congratulate Dr. rer. nat. Michelle Ng on an excellent virtual PhD defense. Following this, she graduated from the HBRS Molecular Medicine PhD program with highest honours.
Dorit completes a successful PhD defense amid social distancing
Many congratulations to Dr. rer. nat. Dorit Schneider, who overcame pandemic-related challenges and successfully defended her PhD! She completed the Molecular Medicine program with a magna cum laude.
Review of RNA-binding proteins and their role in acute leukemias
This review summarizes recent research on RBPs with roles in acute leukemias, focusing on the proteins' functional domains, the pathways they affect, and clinical aspects associated with their dysregulation.
Prof. Klusmann wins the 2020 Johann Georg Zimmermann Prize
Prof. Klusmann was awarded this year's Johann Georg Zimmermann Prize, which recognizes outstanding young investigators for their contribution to the fight against cancer.
HOXA10-AS in the pathogenesis of MLL-rearranged leukemias
Our latest publication reports on the characterization of HOXA10-AS, a novel stem cell-specific lncRNA that is required for the maintenance of MLL-rearranged acute myeloid leukemias.
Maurice is awarded the 2019 Cord-Michael Becker Prize
Our congratulations to Maurice, who won this year's Cord-Michael Becker Prize for his outstanding PhD work in the field of Molecular Medicine. This is a highly prestigious national award!
Dorit wins a Young Investigator Prize at ISEH 2019
At this year's ISEH meeting in Brisbane, Australia, Dorit won both a travel award as well as a Young Investigator Prize for her short talk on EZH2 loss and co-operating mutations. We are so proud!
Dirk Heckl becomes professor of Experimental Pediatrics in Halle
Our congratulations to Dirk Heckl, who has now officially joined the faculty of the Universitätsklinikum Halle as professor of Experimental Pediatrics, after more than a year apart.
Molecular drivers of leukemia progression from TAM to ML-DS
Two of our papers went online this week! 1) Identification and validation of molecular events that drive progression from transient abnormal myelopoiesis to full-blown Down syndrome myeloid leukemia.
Review of long noncoding RNAs in acute myeloid leukemia
Two of our papers went online this week! 2) A review article on the regulatory roles of long noncoding RNAs in acute myeloid leukemia, including an updated catalog of functionally defined examples.
Sofia defends her PhD thesis with top honours
Another excellent PhD defense this year! Congratulations to Dr. rer. nat. Sofia Gialesaki, who graduated with a summa cum laude in June - among the first from the PhD program's entering class of 2015!
Sofia presents in the Presidential Symposium of EHA 2019
We are very proud of Sofia, who won a YoungEHA Best Abstract Award and presented the RUNX1 story to thousands during the EHA 2019 Presidential Symposium today. Yay Sofia!
Maurice recieves top honours for his PhD thesis
Following an excellent thesis defense, Dr. rer. nat. Maurice Labuhn graduated with a summa cum laude from the HBRS Molecular Medicine PhD program. Many congratulations!
Low-dose cytarabine reduces mortality in TMD patients
The TMD Prevention 2007 trial found that low-dose cytarabine treatment reduced mortality in TMD patients. However, this therapy did not prevent disease progression to ML-DS.
Seeking applicants for a postdoc position in Halle
We have an open position for a skilled and dedicated postdoc in our new laboratory in Halle. Applications are welcome until the end of February. See the full post for more details.
Porta donates to Down syndrome leukemia research
The proceeds from this year's Charity Day were given to Pediatrics I of the Universitätsklinikum Halle. The funds will support research on leukemia in children with Down sydrome.
The developmental stage-specific effects of GATA1s
CRISPR-Cas9 genome editing was used to induce GATA1s in HSPCs of fetal, neonatal, and adult origin, leading to distinct ontogeny-specific disturbances in megakaryopoiesis and erythropoiesis.
Therapeutic and prognostic value of miR-193b in AML
The tumor suppressor miR-193b is downregulated in AML. Expression induces leukemic cell death through repression of MAPK signalling, making miR-193b a candidate for RNA-based therapy.
Towards improving sgRNA efficacy prediction
Introducing CRISPRater: a tool for more efficiently selecting effective sgRNAs in CRISPR-Cas9 applications. In addition, we provide a meta-analysis and individual evaluation of five current prediction algorithms.
Jan-Henning Klusmann to be a Department Head in Halle
Jan-Henning Klusmann will become full professor and department head of Pediatric Hematology/Oncology at the Universitätsklinikum Halle! He will begin there in January, and students will follow in March.
The 2017 International Arceci Award funds two researchers
PD Dr. Jan-Henning Klusmann is a co-winner of the this year's Robert J. Arceci Award, a unique prize that offers resources and freedom to pioneers and innovators in childhood cancer research.
The non-coding RNA landscape of human hematopoiesis
Our latest publication provides a non-coding RNA expression atlas across normal and malignant blood cells. We highlight the biological and clinical importance of ncRNAs, and the need for further study.
Modeling leukemogenesis with CRISPR-Cas9
Two publications in one day: 1) Leveraging CRISPR-Cas9 to model translocation-driven leukemia yields new insight into the importance of environmental cues during disease induction.
CRISPR-Cas9 gene correction in Kostmann disease
Two publications in one day: 2) Targeted gene correction in induced pluripotent stem cells from Kostmann disease patients reverted the disease phenotype and rescued granulocytic function.
Seeking applicants for postdoctoral research position
We are looking for a proactive and creative team player capable of designing and carrying out experiments independently. Experience with cell culture and molecular biology preferred.
Reduced therapy for Down syndrome myeloid leukemia
Results from the international ML-DS 2006 trial indicate that children with Down syndrome acute myeloid leukemia can be cured with a less intensive, less cytotoxic treatment regime.
The 16th International Symposium on Acute Leukemias
All five of our PhD students showed posters at the ISALXVI in Munich. Dorit was further selected as a Best of Free Contributions and gave a talk and interview about her research.
Erik successfully defends his PhD thesis
Congratulations to Dr. rer. nat. Erik Pittermann, who has graduated from the Regenerative Sciences PhD program (HBRS/REBIRTH Cluster of Excellence) with a magna cum laude grade.
1.5 million Euros for infant leukemia research
PD Dr. Jan-Henning Klusmann's "iAML-lncTARGET" project has received 1.5 million Euros in funding from the European Research Council's (ERC) prestigious ERC Starting Grant.
Disturbed waste disposal in leukemia cells
In collaboration with a multi-national group, we have succeeded in targeting cancer cells by blocking autophagy. This may represent a new therapeutic option for treating acute leukemias.
The Evangelische Johannesstift funds leukemia research
The Evangelische Johannesstift has donated 364,000 Euros to fund research on early childhood leukemias. PD Dr. Jan-Henning Klusmann of Pediatric Hematology and Oncology was the recipient.
Razan successfully completes her PhD defense
Congratulations to Dr. Razan Jammal, who graduated today from the HBRS Molecular Medicine PhD program. She successfully defended her thesis and received a magna cum laude.
The 29th Annual Kind Philipp Meeting in Wilsede
Eight of our students presented their work this year at the 29th Annual Kind Philipp Meeting in Wilsede. Michelle received the first Kind Philipp Presentation Award for unpublished research.
Erik receives the first Zellkraftwerk Prize
At this year's Johannes Brodehl Symposium, Erik Pittermann was awarded the first "Zellkraftwerk Nachwuchsforscherpreis" (Prize for Young Scientists) for his promising PhD work.
PD Dr. Jan-Henning Klusmann recieves Kind-Philipp Prize
Dr. Jan-Henning Klusmann has received the 10,000 Euro Kind-Philipp Prize, in appreciation of his research work on childhood blood cancers at the Hannover Medical School.
Small genes with great effects: towards new leukemia therapies
Dr. Klusmann's research group reveals the interplay between three microRNAs in the development of acute megakaryoblastic leukemia. Their findings were published in Genes & Development.