We are seeking applicants for a postdoctoral research position! Please find the complete announcement with details below. Applications can be sent to PD Dr. Jan-Henning Klusmann (https://www.leukemia-research.de/pd-dr-jan-henning-klusmann/).

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The ERC-funded research group of PD Dr. Jan-Henning Klusmann in the Depatrment of Pediatric Hematology and Oncology is currently seeking applicants for a postdoctoral research position investigating the biology of acute myeloid leukemia (AML).

Aiming to understand the step-wise development, we focus on children with Down syndrome, who are significantly predisposed towards developing AML. Our group has made essential contributions towards identifying both coding and non-coding genes on chromosome 21 involved in disease pathogenesis, at the center of which is GATA1. With advanced molecular biology methodologies, we now aim to delineate the mechanisms and interaction partners of mutated GATA1, the oncogenic networks on chromosome 21, and co-occurring mutations during the transformation into Down syndrome AML.

High-throughput screening platforms (shRNA and CRISPR-Cas9 based) and cellular assays in primary hematopoietic stem cells and patient samples, coupled to advanced flow cytometry, chromatin immunoprecipitation, gene expression analysis, and protein pulldown will all be part of the applied techniques. Hannover Medical School provides state-of-the-art facilities for conducting this innovative research project. The close connection between our research group and the Pediatric Hematology and Oncology clinics facilitates our translational research and the transfer of scientific findings to clinical studies.

Desired skills and experience: Applicants are expected to hold a PhD or Dr. rer. nat. in the field of cancer biology, cell biology, molecular biology, biochemistry, or biomedicine, and a publication track record that demonstrates innovative scientific achievements. A FELASA certificate (or equivalent) is required. We are looking for an enthusiastic, proactive, and creative team player with the ability to develop and perform experiments independently. Experience with tissue culture and molecular biology is highly preferred.

Benefits: We offer an initial contract of 2 years, with the option of extending for up to 5 years. It is a full-time position with flexible working hours not suitable for part-time. The salary will be based on personal qualifications and requirements according to the agreement of the “Tarifgemeinschaft der Länder (TvL)”.

The MHH is committed to the advancement of women in professional life. Applications from women are therefore particularly welcome. Severely disabled applicants with equal qualifications will be given preference.

More information about our projects and team is available on our website (www.leukemia-research.de). For questions, please contact PD Dr. Jan-Henning Klusmann via email. In your application, please include a cover letter, your CV, and a short description of your methodological background. Applications can be sent to PD Dr. Klusmann via email until June 13th, 2017.