Prof. Dr. Jan-Henning Klusmann

Jan-Henning is an ERC grant holder, Professor, and Director of Pediatrics at the Goethe University Frankfurt.

Lonneke Verboon

Lonneke (PhD student & Scientific Coordinator) is investigating interactions within the DLK1-DIO3 non-coding RNA locus in normal and malignant megakaryopoiesis.

Dr. Xiaoyan Wei

Postdoctoral Researcher

Anna-Lena Schmell

Anna-Lena (PhD student) is performing CRISPR/Cas9-based screens to repurpose the use of FDA-approved therapeutics in ML-DS patients.

Leah Schüler

Leah (PhD student) is performing CRISPR/Cas9 screens in vitro and in vivo of long non-coding RNAs to characterize the underlying fetal-specific oncogenic trascriptional signature of infant AML.

David Groll

David (Phd student) is performing CRISPR/Cas9 screens exploring the fetal origin of leukemias.

 

 

Sònia Cases i Palau

Sònia (PhD student) is studying the interplay between GATA1s and secondary mutations during the progression from TAM into ML-DS.

Nina Murmann

Nina (PhD student) is studying epigenetic regulation in development and leukemia.

Amr Abdrbo

Amr (PhD student) studies how the loss of the N-terminal activation domain of GATA1 contributes to leukemia development in pediatric ML-DS.

Katja Rohde

Katja (Phd student) is investiga-ting the relapse mechanism in children with ML-DS.

Robert Winkler

Robert (clinical scientist) is performing CRISPR/Cas-based screens of long noncoding RNAs to discover novel contributors to AML pathobiology.

Stephanie Laszig

Stephanie (clinical scientist) is working on the ML-DS clinical trial and developing immunotherapeutics for pediatric AML.

Daniela Koch

Daniela (clinician scientist) is investigating metabolic dependencies in pediatric AML through PDX-based multi-omics.

Cihan Agca

(Clinican Scientist)

Katharina Merkewitz

Katharina (technician) supports the in vitro aspect of the non-coding RNA and modeling AML projects.

Franziska Ganß

Franziska (technician) supports the FACS sorting of the ML-DS and AML clinical and research projects.

Daniel Belzer

Daniel (technician) is working on maintaining a patient derived xenograft biobank for pediatric leukemias.

Victoria Lang

Victoria (technician) is working on identifying and testing novel therapeutic treatment options for acute myeloid leukemia in pediatrics.

Dr. José Gonçalves-Dias

José (bioinformatician) performs multi-omics analysis for decoding the mutational epigenetics landscape of pediatric leukemia.

Konstantin Schuschel

Konstantin (PhD student & bioinformatician) works on the discovery of novel fusion transcripts involved in leukemia and performs multi-omic analysis on large patient cohorts.

Emilia Salzmann-Manrique

Emilia (Biostatistician) works in biomedical statistics and data science, focusing on clinical trial studies and research projects.

Prof. Dr. Dirk Heckl

Dirk is the director of the institute for paediatric haematology and oncology in Frankfurt. He specializes in CRISPR-Cas9 systems and modeling leukemia in mice.

Luca Cifarelli

Luca (PhD student, independent) is modeling de novo translocation-driven leukemogenesis and cooperating mutations using CRISPR-Cas9.

Elif Özcan

Elif (Phd student) is investigating the oncofetal reprogramming in pediatric AML using CRISPR-Cas9 screens.

Johannes Haas

Johannes (Phd student) combines CRISPR Cas13 multiplexing and prime editing to map genetic drivers and identify therapeutic vulnerabilities in AML.

Leonie Mair

Phd student

Sabrina Schuster

Phd student

Matija Kovic

Matija (PhD student) is designing innovative immunotherapies for ML-DS  as a strategy to reduce relapse rates and improve long-term remission.

Sara Jamous

(PhD Student)

Dr. med. Celia Kaffenberger

Dr. med. Celia Kaffenberger (Clinician Scientist) explores innovative strategies to enhance immune-based therapies in pediatric AML.

Klara Malburg

Klara (Medical Student) is exploring drug synergies in possible combination therapies of pediatric AML.

Pascal Kunik

Pascal (Medical Student) is performing CRISPR-based screens to study the potential RBP targets in cooperation with EZH2 in leukemogenesis.

Shaole Song

technican

Prof. Dr. Christian Braun

Christian (Dr. Rolf M. Schwiete Professor for Translational Pediatric Oncology) combines genome-scale CRISPR perturbation platforms, in vivo functional screening, and mechanistic studies in his research.

Dr. Mark Rassner

Mark (Clinician Scientist, M.Sc.) explores how specific inhibition of transcription can be exploited to tackle aberrant tumor transcriptomes

Melina Bäuerle

Melina (PhD student, M.Sc.) identifies and investigates novel RNA life cycle vulnerabilities to exploit them for the molecular therapy of pancreatic ductal adenocarcinoma.

Robert Lersch

Robert (Clinician Scientist, M.D.) investigates the aberrant transcriptome of diffuse midline gliomas and explores RNA metabolism as a therapeutic vulnerability.

Paul Reißig

Paul (Technician, M.Sc.) investigates mechanisms of pediatric brain tumors using iPSC-derived differentiation models.

Dr. Eva Rettinger

Group leader

Elisa Hopke

Elisa (PhD student) is developing a CAR-CIK cell therapy for relapsed/refractory pediatric AML.

Aljoscha Lübbers

Aljoscha (Medical Student) is exploring the effect of various cytokines on cytokine-induced killer cells and assessing the cytotoxicity against different pediatric neoplasms.

Dr. Hannah Uckelmann

Hannah (Max-Eder junior research group leader) works on NPM1c-driven leukemogenesis with focus on novel therapeutic therapies in NPM1 mutant AML.

Sara Gama

Sara (PhD student) works on NPM1c-driven leukemogenesis with focus on novel therapeutic therapies in NPM1 mutant AML.

Hannah Gonzalez

Hannah (PhD student) examines the role of the nuclear export factor XPO1 on chromatin in NPM1c-driven AML.

Arezo Javadpoor

Arezo (PhD student) works on exploring the epigenetic regulation of leukemia development.

Marcel Müller

Marcel (PhD student) is exploring the epigenetic mechanisms regulating oncogenic stem cell programs.

Ismael Almeida

(Phd Student)

Cansu Üstüner

Cansu (technican) supports the team experimentally with immunocytochemistry and microscopy applications for the investigation of NPM1c driven AML.

Dr. Marit Willemijn Vermunt

Marit’s Max-Eder junior research group investigates CTCF, antisense transcription and DNA methylation in cancer.

Zijin Zhang

Zijin (Phd Student) works on the identification of antisense transcripts, and investigates their role in pediatric leukemia.

Tairan Zhong

Tairan (PhD student) studies clonal evolution and therapy resistance in leukemia.

Gemma Hughes-Waldon

Gemma (technican) supports tissue culture and wet lab experiments that are centered around CTCF and (noncoding) RNA.

Lavinia Grob

Lavinia (technican) supports tissue culture and molecular studies focused on antisense transcription and the role of transient enhancers in erythroid differentition.

Alumni

View a list of past lab members.