Pediatric and Experimental Hematology

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AG Klusmann

Prof. Dr. Jan-Henning Klusmann

Jan-Henning is an ERC grant holder, Professor, and Director of Pediatrics at the Goethe University Frankfurt.

Lonneke Verboon

Lonneke (PhD student, independent) is investigating interactions within the DLK1-DIO3 non-coding RNA locus in normal and malignant megakaryopoiesis.

Anna-Lena Schmell

Anna-Lena (PhD student) is performing CRISPR/Cas9-based screens to repurpose the use of FDA-approved therapeutics in ML-DS patients.

David Groll

David (Phd student) is performing CRISPR/Cas9 screens exploring the fetal origin of leukemias.



Kenza Benhassine

Kenza (technician) supports the in vitro aspect of the non-coding RNA and modeling AML projects.

Katharina Merkewitz

Katharina (technician) supports the in vitro aspect of the non-coding RNA and modeling AML projects.

Franziska Ganß

Franziska (technician) supports the FACS sorting of the ML-DS and AML clinical and research projects.

José Gonçalves Dias

José (bioinformatician) performs multi-omics analysis for decoding the mutational epigenetics landscape of pediatric leukemia.

Konstantin Schuschel

Konstantin (bioinformatical PhD student, independent) works on the discovery of novel fusion transcripts involved in leukemia and performs multi-omic analysis on large patient cohorts.


Dr. Hasan Issa

Hasan (postdoctoral fellow) works on epigenetic profiling of naive and malignant hematopoiesis, and modeling AML progression in primary human stem cells.

Sònia Cases i Palau

Sònia (PhD student) is studying the interplay between GATA1s and secondary mutations during the progression from TAM into ML-DS.

Katja Rohde

Katja (Phd student) is investiga-ting the relapse mechanism in children with ML-DS.

AG Heckl

Prof. Dirk Heckl

Dirk is the director of the institute for paediatric haematology and oncology in Frankfurt. He specializes in CRISPR-Cas9 systems and modeling leukemia in mice.

Luca Cifarelli

Luca (PhD student, independent) is modeling de novo translocation-driven leukemogenesis and cooperating mutations using CRISPR-Cas9.

Elif Özcan

Elif (Phd student) is investigating the oncofetal reprogramming in pediatric AML using CRISPR-Cas9 screens.

Xiang Fan

Xiang (PhD student) is performing CRISPR-based screens to study the potential RBP targets in cooperation with EZH2 in leukemogenesis.

Johannes Haas

Phd student

 

 

AG Bhayadia

Dr. Raj Bhayadia

Raj (MSNZ Junior group leader) works on patient-dervied xenograft models of pediatric AML, in vivo non-coding RNA studies, and pre-clinical drug testing.

Leah Schüler

Leah (PhD student) is performing CRISPR/Cas9 screens in vitro and in vivo of long non-coding RNAs to characterize the underlying fetal-specific oncogenic trascriptional signature of infant AML.

Stephanie Laszig

Stephanie (clinical scientist) is working on the ML-DS clinical trial and developing immunotherapeutics for pediatric AML.

Liz Reitemeier

Liz (medical student) using CRISPR based approaches to explore further treatment options in pediatric leukemia.

Robert Winkler

Robert (assistant physican) is performing CRISPR/Cas-based screens of long noncoding RNAs to discover novel contributors to AML pathobiology.

Michelle Christmann

Michelle (technician) supports the in vitro aspect of the non-coding RNA and modeling AML projects.

AG Uckelmann

Dr. Hannah Uckelmann

Hannah (Max-Eder junior research group leader) works on NPM1c-driven leukemogenesis with focus on novel therapeutic therapies in NPM1 mutant AML.

Sara Gama

Sara (PhD student) works on NPM1c-driven leukemogenesis with focus on novel therapeutic therapies in NPM1 mutant AML.

Hannah Gonzalez

PhD student

Arezo Javadpoor

PhD student

Viktoria Wingenfeld

Viktoria (technician) is supporting the in vitro research on NPM1 mutant AML.

AG Vermunt

Dr. Marit Willemijn Vermunt

Marit (junior group leader) works on transcriptional regulation in normal as well as malignant hematopoiesis with a focus on the interplay between CTCF and noncoding RNAs.

Zijin Zhang

(Phd Student)

Alumni

View a list of past lab members.