Our latest BLOOD paper unravels the importance of RUNX1 isoform equilibrium and its interaction with the oncogenic players GATA1s and the MYC:MAX complex.
This week we were awarded a new funding over 2.7 million from the association “Hilfe für krebskranke Kinder”. This money will help us to discovery new therapeutics for pediatric AML.
Oriol Alejo-Valle's work was published as a Plenary Paper in BLOOD. We describe the molecular basis for the dual differentiation block in Down syndrome megakaryoblastic leukemia.
From the clinical side of our lab: Sina presents recommendations for the diagnosis and treatment of children with transient abnormal myelopoiesis and Down syndrome myeloid leukemia.
Congratulations to Dr. rer. nat. Oriol Alejo-Valle on a successful PhD dissertation! His is the first defense from our group that has been held in Halle, and concludes our "batch from 2015".
Another partial lab move is coming up! As of July 1st, Prof. Klusmann has joined the Universitätsklinikum Frankfurt as Head of Pediatrics. Students and postdocs will follow in October.
In our latest review article, we provide a comprehensive overview of the molecular basis of step-wise leukemogenesis in Down syndrome-associated myeloid leukemia and transient abnormal myelopoiesis.
We congratulate Dr. rer. nat. Michelle Ng on an excellent virtual PhD defense. Following this, she graduated from the HBRS Molecular Medicine PhD program with highest honours.
Many congratulations to Dr. rer. nat. Dorit Schneider, who overcame pandemic-related challenges and successfully defended her PhD! She completed the Molecular Medicine program with a magna cum laude.
This review summarizes recent research on RBPs with roles in acute leukemias, focusing on the proteins' functional domains, the pathways they affect, and clinical aspects associated with their dysregulation.