RUNX1 isoform disequilibrium promotes the development of ML-DS
Our latest BLOOD paper unravels the importance of RUNX1 isoform equilibrium and its interaction with the oncogenic players GATA1s and the MYC:MAX complex.
3 Mio € Funding promoting the search for new AML Treatments
This week we were awarded a new funding over 2.7 million from the association “Hilfe für krebskranke Kinder”. This money will help us to discovery new therapeutics for pediatric AML.
A new regulator of myeloid leukemia identified
Oriol Alejo-Valle's work was published as a Plenary Paper in BLOOD. We describe the molecular basis for the dual differentiation block in Down syndrome megakaryoblastic leukemia.
Guidelines for diagnosis and treatment of TAM and ML-DS
From the clinical side of our lab: Sina presents recommendations for the diagnosis and treatment of children with transient abnormal myelopoiesis and Down syndrome myeloid leukemia.
Oriol successfully defends his PhD thesis in Halle
Congratulations to Dr. rer. nat. Oriol Alejo-Valle on a successful PhD dissertation! His is the first defense from our group that has been held in Halle, and concludes our "batch from 2015".
Prof. Klusmann becomes Head of Pediatrics in Frankfurt
Another partial lab move is coming up! As of July 1st, Prof. Klusmann has joined the Universitätsklinikum Frankfurt as Head of Pediatrics. Students and postdocs will follow in October.
Review of molecular mechanisms underlying TAM and ML-DS
In our latest review article, we provide a comprehensive overview of the molecular basis of step-wise leukemogenesis in Down syndrome-associated myeloid leukemia and transient abnormal myelopoiesis.
Michelle defends PhD thesis summa cum laude
We congratulate Dr. rer. nat. Michelle Ng on an excellent virtual PhD defense. Following this, she graduated from the HBRS Molecular Medicine PhD program with highest honours.
Dorit completes a successful PhD defense amid social distancing
Many congratulations to Dr. rer. nat. Dorit Schneider, who overcame pandemic-related challenges and successfully defended her PhD! She completed the Molecular Medicine program with a magna cum laude.
Review of RNA-binding proteins and their role in acute leukemias
This review summarizes recent research on RBPs with roles in acute leukemias, focusing on the proteins' functional domains, the pathways they affect, and clinical aspects associated with their dysregulation.